Introduction
Budesonide is a glucocorticoid with highly effective local anti-inflammatory effects. It can enhance the stability of the membranes of endothelial cells, smooth muscle cells, and lysosomes, inhibit immune responses, and reduce antibody synthesis. As a result, it decreases the release and reduces the activity of allergic mediators such as histamine. Moreover, it can alleviate the enzymatic processes triggered when antigen and antibody bind, and inhibit the synthesis and release of substances that cause bronchoconstriction, thereby reducing the contraction response of smooth muscles. Clinically, it is used for patients with glucocorticoid-dependent or non-dependent bronchial asthma and asthmatic chronic bronchitis.
Specifications
In house
Chemical Name
16α,17α - Butylidenebis(oxy) - 11β,21 - dihydroxy - pregna - 1,4 - diene - 3,20 - dione.
Molecular formula
C25H34O6
CAS NO.
51333-22-3
Packing
1kg/tin
Category
Glucocorticoid steroid.
Storage
Store in a dark place and keep it sealed.
Indication
Respiratory Disorders
It is widely used in the treatment of asthma. Inhaled budesonide helps control airway inflammation, reduces the frequency and severity of asthma attacks, and improves lung function. It is also used in the management of chronic obstructive pulmonary disease (COPD) to relieve inflammation and improve respiratory symptoms.
Gastrointestinal Disorders
Budesonide is available in oral - controlled release formulations for the treatment of inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. It acts locally in the intestine to reduce inflammation and alleviate symptoms like abdominal pain, diarrhea, and rectal bleeding.
Nasal Disorders
Nasal sprays containing budesonide are used for the treatment of allergic and non - allergic rhinitis. They help relieve nasal congestion, itching, sneezing, and rhinorrhea by reducing inflammation in the nasal mucosa.
Pharmacology
Anti - Inflammatory Action: Budesonide is a corticosteroid with potent anti - inflammatory, immunosuppressive, and anti - allergic effects. It acts by binding to glucocorticoid receptors in the cytoplasm of target cells. The hormone - receptor complex then translocates to the nucleus and modulates the transcription of genes involved in the inflammatory response, reducing the production of inflammatory mediators like cytokines, chemokines, and leukotrienes.
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