Introduction
Ciclesonide is a synthetic corticosteroid. It is primarily used in the treatment of various respiratory and allergic conditions. It is available in different formulations, including inhalers for the treatment of asthma and nasal sprays for allergic rhinitis.
Specifications
In house
Chemical Name
(R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate
Molecular formula
C32H44O7
CAS NO.
126544-47-6
Packing
1kg/tin
Category
Glucocorticoid steroid.
Storage
Store in a dark place and keep it sealed.
Indication
Asthma
Inhaled ciclesonide is used for the maintenance treatment of asthma in patients aged 12 years and older. It helps to control asthma symptoms, reduce the frequency of exacerbations, and improve lung function.
Allergic Rhinitis
Nasal ciclesonide is indicated for the treatment of seasonal and perennial allergic rhinitis in patients aged 6 years and older. It relieves symptoms such as nasal congestion, rhinorrhea, itching, and sneezing.
Pharmacology Properties
Mechanism of Action
Ciclesonide is a prodrug. Once inhaled or applied nasally, it is hydrolyzed in the body to its active metabolite, des - isobutyryl - ciclesonide. This active metabolite binds to glucocorticoid receptors in target cells, mainly in the airways or nasal mucosa. It then regulates gene expression, inhibiting the production and release of inflammatory mediators such as cytokines, leukotrienes, and prostaglandins. This helps to reduce inflammation, swelling, and mucus production, thereby improving respiratory function and relieving nasal symptoms.
Pharmacokinetics
After inhalation or nasal administration, ciclesonide is rapidly absorbed and converted to its active metabolite. The active metabolite has a relatively long - half life, which allows for once - or twice - daily dosing. It is metabolized in the liver and excreted mainly in the feces, with a small amount excreted in the urine.
Dosage and Administration
Inhaled Ciclesonide
For asthma, the usual starting dose is 80 - 160 mcg twice daily. The dose may be adjusted based on the patient's response. It is important to use the inhaler as directed, usually by inhaling the medication while breathing in deeply.
Nasal Ciclesonide
For allergic rhinitis, the recommended dose is usually 200 mcg (two sprays in each nostril) once daily. In some cases, the dose may be increased to 400 mcg (four sprays in each nostril) once daily for better control of symptoms.
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