Introduction
16alpha-Hydroxyprednisolone acetate, also known as 16α-Hydroxyprednisolone acetate, is a kind of chemical intermediate.
Specifications
In house
Chemical Name
11β,16α - Dihydroxy - 17 - (1 - oxopropoxy) - pregna - 1,4 - diene - 3,20 - dione.
Molecular formula
C₂₃H₃₀O₆
CAS NO.
13951-70-7
Packing
1kg/tin
Category
Intermediates
Storage
Store in the dark and keep it sealed.
Indication
Inflammatory and Autoimmune Disorders
It is used to treat a variety of inflammatory and autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, asthma, and inflammatory bowel disease. By suppressing the immune system and reducing inflammation, it helps to relieve symptoms such as pain, swelling, and tissue damage.
Allergic Reactions
It can be used to manage severe allergic reactions, such as anaphylaxis and drug - induced allergies, by suppressing the allergic immune response.
Skin Disorders
It is sometimes used topically or systemically to treat skin conditions like eczema, psoriasis, and contact dermatitis, helping to reduce inflammation and itching.
Adrenal Insufficiency
In cases of adrenal insufficiency, 16 - a Hydroxy Prednisolone can be used as a replacement therapy to supplement the deficient corticosteroids.
Pharmacology Properties
Pharmacological Class: It belongs to the class of corticosteroids.
Mechanism of Action: Similar to other corticosteroids, 16 - a Hydroxy Prednisolone exerts its effects by binding to glucocorticoid receptors in cells. This complex then translocates to the nucleus and modulates gene expression, leading to anti - inflammatory, immunosuppressive, and other effects. It inhibits the production and release of various inflammatory mediators such as cytokines, prostaglandins, and leukotrienes, thereby reducing inflammation and suppressing the immune response.
Dosage and Administration
The dosage of 16 - a Hydroxy Prednisolone varies depending on the specific condition being treated, the patient's age, weight, and overall health. For oral administration, the usual starting dose can range from 5 to 60 mg per day, depending on the severity of the disease. The dose is often adjusted based on the patient's response and may be tapered gradually as the condition improves to minimize side effects. In some cases, it may be administered intravenously or intramuscularly for more rapid onset of action or in severe cases. For topical use in skin disorders, creams or ointments containing the drug are applied to the affected area as directed.
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