Introduction
Fluocinonide, also known as fluocinonide ester, is a commonly used potent topical anti-inflammatory glucocorticoid drug in clinical practice. It is widely applied in the treatment of various diseases such as dermatitis, eczema, psoriasis, lupus erythematosus, lichen planus, and osteoarthritis.
Specifications
CP
Chemical Name
6α,9-Difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione,cyclic 16,17 acetal with acetone,21 actate.
Molecular formula
C26H32F2O7
CAS NO.
356-12-7
Packing
1kg/tin
CERTIFICATE
GMP
Category
Glucocorticoid steroid.
Storage
Store in a dark place and keep it sealed.
Indication
It is used for the treatment of various skin conditions, including eczema, psoriasis, dermatitis, and other inflammatory and pruritic skin disorders. It helps to relieve itching, redness, swelling, and inflammation of the skin.
Pharmacology
Mechanism of Action
Fluocinonide exerts its anti - inflammatory, antipruritic, and vasoconstrictive effects by binding to glucocorticoid receptors in the cytoplasm of target cells. This leads to the modulation of gene expression, resulting in the inhibition of various inflammatory mediators and cytokines, thereby reducing inflammation and itching.
Pharmacokinetics
After topical application, a small amount of fluocinonide is absorbed through the skin into the systemic circulation. It is metabolized in the liver and excreted mainly through the kidneys.
Dosage and Administration
For topical use, it is usually applied to the affected area 2 to 3 times daily. The amount of the drug applied should be the minimum necessary to cover the affected area. In some cases, for more severe conditions, occlusion (covering the treated area with a dressing) may be used under the guidance of a doctor, but this should be done with caution to avoid excessive absorption and potential side effects.
Side Effects and Adverse Reactions
Local Side Effects
Common local side effects include skin atrophy, striae, telangiectasia, folliculitis, and contact dermatitis. Prolonged or excessive use may lead to pigmentation changes and secondary infections.
eSystemic Side Effects
Although rare with topical use, systemic side effects can occur, especially with extensive use or use under occlusion. These may include adrenal suppression, Cushing's syndrome - like symptoms (such as weight gain, moon face, buffalo hump), hyperglycemia, and osteoporosis.
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