Introduction
Artemether is a highly effective and rapid schizontocide acting on the intraerythrocytic stage of the malaria parasite. It is used for the treatment of chloroquine-resistant falciparum malaria and severe malaria. It shows a quick onset of action and has a good therapeutic effect.
Specifications
In house/CP
Chemical Name
(3R, 5aS, 6R, 8aS, 9R, 10S, 12R,
12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
Molecular formula
C16H26O₅
CAS NO.
71963-77-4
Packing
1kg/tin
INDICATION
It is a drug used to treat malaria.Mainly used in the chloroquine-resistant falciparum malaria.
Category
Anti-malarial drugs.
Storage
2-8℃
Pharmacological Actions
Antimalarial Mechanism: Artemether exerts its antimalarial effect by generating free radicals after interacting with the heme - iron in the digestive vacuole of the malaria parasite. These free radicals alkylate and damage the parasite's biomolecules, such as DNA and proteins, leading to the inhibition of parasite growth and replication. It has a rapid - acting effect, especially effective against the asexual erythrocytic stage of the malaria parasite, which is the stage that causes the symptoms of malaria.
Clinical Applications
Treatment of Malaria: It is widely used for the treatment of uncomplicated and severe malaria. In areas where malaria is endemic, artemether - based combination therapies are the first - line treatment options recommended by the World Health Organization. For example, artemether - lumefantrine is commonly used. It can quickly reduce the parasite load in the blood, relieve symptoms such as fever, and improve the patient's condition. It is also effective in preventing the recurrence of malaria.
Administration and Dosage
Oral Route
As mentioned earlier, for artemether - lumefantrine, the dosage for uncomplicated malaria is based on body weight. For adults, the typical regimen is 4 tablets twice a day on the first day, followed by 4 tablets once a day on the second and third days. The tablets should be taken with food, preferably a fatty meal, to enhance the absorption of the drugs.
Intramuscular Injection
In cases of severe malaria or when the patient cannot take oral medications, artemether can be administered by intramuscular injection. The dosage is usually calculated based on the patient's weight and the severity of the condition. A loading dose is often given initially, followed by maintenance doses at specific intervals.
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