Introduction
Ozagrel sodium is an important drug for the treatment and prevention of thrombotic diseases, especially in the field of cerebrovascular diseases.
Specifications
In house/CP
Chemical Name
Sodium (E)-3-(4 - hydroxyphenyl)-2 - (prop - 2 - en - 1 - yl) oxycarbonyl-2 - propenoate.
Molecular formula
C13H11NaO4
CAS NO.
189224-26-8
Packing
1kg/tin
Category
Anticoagulant drugs
Storage
Protect from light, seal the container, and store in a cool place.
Indication
It is used for the treatment of acute thrombotic cerebral infarction and the motor disorders accompanied by cerebral infarction, as well as for improving the vasospasm and contraction of cerebral blood vessels after subarachnoid hemorrhage surgery and the concurrent cerebral ischemic symptoms.
Pharmacological Actions
Antithrombotic Effect
Ozagrel sodium is a potent inhibitor of thromboxane A₂ synthase. It can effectively reduce the production of thromboxane A₂, which is a substance that promotes platelet aggregation and vasoconstriction. By inhibiting thromboxane A₂ synthase, ozagrel sodium can prevent platelet aggregation and the formation of thrombi, thereby playing a role in preventing and treating thrombotic diseases.
Vasodilatory Effect
In addition to its antithrombotic effect, ozagrel sodium also has a certain vasodilatory effect. It can relax blood vessels, improve blood circulation, and increase blood flow to ischemic tissues, which is beneficial for improving the blood supply of organs and tissues.
Clinical Applications
Treatment of Cerebrovascular Diseases
Ozagrel sodium is mainly used in the treatment of acute cerebral infarction and its sequelae. It can improve the neurological function of patients, reduce the area of cerebral infarction, and improve the prognosis of patients. By inhibiting platelet aggregation and improving cerebral blood flow, it helps to relieve the symptoms of cerebral ischemia and promote the recovery of brain function.
Prevention of Thrombosis in Other Diseases
It can also be used in some other diseases with a high risk of thrombosis, such as in patients with cardiovascular diseases or those undergoing certain surgical procedures, to prevent the occurrence of thrombotic complications.
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