Introduction
Feprazone is a pyrazolone - based non - steroidal anti - inflammatory drug, which has anti - inflammatory, analgesic and certain antipyretic effects. Its anti - inflammatory effect is comparable to or superior to that of phenylbutazone and indomethacin, and its analgesic effect is slightly stronger. It is rapidly absorbed in the intestine. The peak plasma concentration is reached within 4 - 6 hours. The plasma half - life is about 20 hours. After being metabolized in the body, it is excreted in the urine in the form of metabolites. Clinically, it is used for the treatment of rheumatoid and rheumatic arthritis, osteoarthritis, ankylosing spondylitis, and fibrositis, etc.
Specifications
CP
Chemical Name
4 - Benzoyl - 1 - phenyl - 3 - thiosemicarbazide
Molecular formula
C20H20N2O2
CAS NO.
30748-29-9
Packing
1kg/tin
Category
Nonsteroidal Antiinflammatory Drugs
Storage
Store in the dark and keep it sealed.
Indication
Rheumatic and Rheumatoid Arthritis
It can relieve joint pain, swelling, and stiffness, improve joint function, and slow down the progression of the disease.
Osteoarthritis
It helps to reduce pain and inflammation in the joints, improve the quality of life of patients with osteoarthritis.
Soft Tissue Inflammation
It is effective in treating inflammation of muscles, tendons, and ligaments, such as myositis, tendonitis, and bursitis.
Other Conditions
It can also be used for the symptomatic treatment of fever, headache, and toothache caused by various reasons.
Pharmacological Actions
Analgesic Effect
It acts on the pain - sensitive receptors in the peripheral and central nervous systems to block the transmission of pain signals, thus relieving pain. It is effective in various types of pain, such as headache, toothache, neuralgia, and joint pain.
Antipyretic Effect
It can act on the hypothalamic thermoregulatory center to promote heat dissipation by increasing peripheral blood flow, vasodilation, and sweating, thereby reducing the elevated body temperature.
Anti - Inflammatory Effect
By inhibiting the synthesis and release of inflammatory mediators such as prostaglandins, leukotrienes, and cytokines, it alleviates the inflammatory response, including redness, swelling, heat, and pain in the inflamed area.
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