Introduction
Ursodeoxycholic acid is used in medicine to increase the secretion of bile acids and alter the composition of bile. It reduces the levels of cholesterol and cholesterol esters in bile, which is beneficial for the gradual dissolution of cholesterol in gallstones.
Specifications
CP
Chemical Name
3α,7β - Dihydroxy - 5β - cholanic acid
Molecular formula
C24H40O4
CAS NO.
128-13-2
Packing
1kg/tin,5kg/tin,25/drum
CERTIFICATE
GMP
Category
Hepatobiliary drugs
Storage
Store in the dark and keep it sealed.
Indication
It is used for treating cholesterol gallstones, cholestatic liver disease, and bile reflux gastritis.
Pharmacology Properties
Mechanism of Action
Ursodeoxycholic acid acts by replacing toxic endogenous bile acids with itself in the bile. It helps to increase the solubility of cholesterol in bile by reducing the cholesterol saturation index. It also has a cytoprotective effect on hepatocytes, protecting them from the toxic effects of bile acids and other harmful substances. Additionally, it can modulate the immune response in the liver and biliary system.
Pharmacokinetic Characteristics
After oral administration, ursodeoxycholic acid is absorbed from the small intestine. It undergoes enterohepatic circulation, meaning it is taken up by the liver, secreted into bile, and then re - absorbed from the intestine. The half - life in the enterohepatic circulation is relatively long. It is metabolized in the liver and excreted mainly in the bile and then in the feces. A small amount is excreted in the urine.
Clinical Applications
Treatment of Gallstones
It is mainly used for the dissolution of cholesterol - rich gallstones in patients who are not suitable for surgery or prefer non - surgical treatment. It can gradually dissolve small cholesterol stones over a period of time.
Liver Diseases
It is also used in the treatment of various liver diseases, such as primary biliary cholangitis, primary sclerosing cholangitis, and some drug - induced liver injuries. It helps to improve liver function tests and slow down the progression of liver diseases by reducing bile stasis and protecting liver cells.
Pediatric Applications
In children, it is used for certain liver and biliary disorders, such as biliary atresia - related cholestasis, to improve bile flow and liver function.
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