Introduction
Indapamide is an organic compound mainly used as an antihypertensive drug. It has the advantages of good curative effect, stable blood pressure reduction, and few side reactions.
Specifications
CP/EP/USP
Chemical Name
N - (2 - methyl - 2,3 - dihydro - 1H - indol - 1 - yl) - 3 - sulfamoyl - 4 - chlorobenzamide; Lozol, Natrilix, etc.
Molecular formula
C16H16O3N3ClS
CAS NO.
26807-65-8
Packing
1kg/tin,5 kg/tin
CERTIFICATE
GMP
Category
Antihypertensive drugs
Storage
Store in the dark and keep it sealed.
Indication
Hypertension
It is commonly used in the treatment of essential hypertension, either as a single - agent therapy or in combination with other antihypertensive drugs.
Edema
It can be used to treat edema associated with various conditions, such as congestive heart failure, liver cirrhosis, and renal insufficiency. However, it is not the first - line drug for severe edema.
harmacological Actions
Classification: It is a sulfonamide - derived diuretic and antihypertensive drug.
Mechanism of Action: Indapamide exerts its diuretic effect by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidney. This leads to an increased excretion of sodium, chloride, and water, thereby reducing extracellular fluid volume and blood volume. As an antihypertensive agent, in addition to the diuretic effect, it also has some vasodilatory effects. It can relax blood vessels by interfering with calcium ion influx into vascular smooth muscle cells, reducing peripheral vascular resistance and thus lowering blood pressure.
Pharmacokinetics
Absorption
Well - absorbed after oral administration, with an absorption rate of about 90%. The peak plasma concentration is reached within 1 - 2 hours.
Distribution
Widely distributed in the body, with a volume of distribution of about 0.5 L/kg. It has a high affinity for vascular smooth muscle cells.
Metabolism
Mainly metabolized in the liver by hydroxylation and conjugation reactions. The metabolites are mostly excreted in the urine.
Excretion
Approximately 70% of the drug is excreted in the urine, and the rest is excreted in the feces. The elimination half - life is about 14 - 18 hours.
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